RO90953B - Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida - Google Patents
Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamidaInfo
- Publication number
- RO90953B RO90953B RO118054A RO11805485A RO90953B RO 90953 B RO90953 B RO 90953B RO 118054 A RO118054 A RO 118054A RO 11805485 A RO11805485 A RO 11805485A RO 90953 B RO90953 B RO 90953B
- Authority
- RO
- Romania
- Prior art keywords
- oxindole
- carboxamide derivatives
- preparing
- methylthio
- trifluoromethyl
- Prior art date
Links
- UYINJAQCJCYCGO-UHFFFAOYSA-N 2-oxo-3h-indole-1-carboxamide Chemical class C1=CC=C2N(C(=O)N)C(=O)CC2=C1 UYINJAQCJCYCGO-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 chloro, methyl Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59066784A | 1984-03-19 | 1984-03-19 | |
| US68488984A | 1984-12-21 | 1984-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO90953A RO90953A (ro) | 1987-02-27 |
| RO90953B true RO90953B (ro) | 1987-02-28 |
Family
ID=27080914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO118054A RO90953B (ro) | 1984-03-19 | 1985-03-19 | Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0155828B1 (en]) |
| JP (1) | JPH03178963A (en]) |
| KR (1) | KR860001874B1 (en]) |
| AR (1) | AR247885A1 (en]) |
| AU (1) | AU552119B2 (en]) |
| BG (1) | BG44203A3 (en]) |
| CA (1) | CA1250832A (en]) |
| CS (1) | CS250680B2 (en]) |
| CY (1) | CY1667A (en]) |
| DE (1) | DE3579716D1 (en]) |
| DK (2) | DK163662C (en]) |
| EG (1) | EG17274A (en]) |
| ES (1) | ES541373A0 (en]) |
| FI (1) | FI85265C (en]) |
| GR (1) | GR850669B (en]) |
| HK (1) | HK75992A (en]) |
| HU (1) | HU194825B (en]) |
| IE (1) | IE57741B1 (en]) |
| IL (1) | IL74630A (en]) |
| MA (1) | MA20379A1 (en]) |
| NO (1) | NO168639C (en]) |
| NZ (1) | NZ211487A (en]) |
| OA (1) | OA07967A (en]) |
| PH (1) | PH20843A (en]) |
| PL (1) | PL145873B1 (en]) |
| PT (1) | PT80116B (en]) |
| RO (1) | RO90953B (en]) |
| YU (1) | YU43869B (en]) |
| ZW (1) | ZW4885A1 (en]) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE41420T1 (de) * | 1984-02-07 | 1989-04-15 | Pfizer | 1,3-disubstituierte 2-oxindole und deren anwendung als analgetische und antiinflammatorische mittel. |
| US4686224A (en) * | 1984-10-31 | 1987-08-11 | Pfizer Inc. | Oxindole antiinflammatory agents |
| DE3621761A1 (de) * | 1986-06-28 | 1988-01-07 | Bayer Ag | Indolylpropionsaeuren |
| RO105052B1 (en) * | 1987-02-02 | 1994-12-01 | Pfizer | Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide |
| GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
| US4952703A (en) * | 1989-05-25 | 1990-08-28 | Pfizer Inc. | Intermediates for making 2-oxindole-1-carboxamides |
| HUP9600855A3 (en) * | 1996-04-03 | 1998-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing tenidap |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3767653A (en) * | 1971-06-28 | 1973-10-23 | Squibb & Sons Inc | Thiazines |
-
1985
- 1985-03-15 GR GR85850669A patent/GR850669B/el not_active IP Right Cessation
- 1985-03-15 IE IE683/85A patent/IE57741B1/en not_active IP Right Cessation
- 1985-03-15 PT PT80116A patent/PT80116B/pt unknown
- 1985-03-15 CA CA000476599A patent/CA1250832A/en not_active Expired
- 1985-03-15 EP EP85301807A patent/EP0155828B1/en not_active Expired - Lifetime
- 1985-03-15 DE DE8585301807T patent/DE3579716D1/de not_active Expired - Lifetime
- 1985-03-17 EG EG173/85A patent/EG17274A/xx active
- 1985-03-18 PL PL1985252433A patent/PL145873B1/pl unknown
- 1985-03-18 NO NO851059A patent/NO168639C/no not_active IP Right Cessation
- 1985-03-18 NZ NZ211487A patent/NZ211487A/xx unknown
- 1985-03-18 KR KR1019850001747A patent/KR860001874B1/ko not_active Expired
- 1985-03-18 AR AR85299771A patent/AR247885A1/es active
- 1985-03-18 AU AU40058/85A patent/AU552119B2/en not_active Expired
- 1985-03-18 ZW ZW48/85A patent/ZW4885A1/xx unknown
- 1985-03-18 DK DK121485A patent/DK163662C/da not_active IP Right Cessation
- 1985-03-18 YU YU428/85A patent/YU43869B/xx unknown
- 1985-03-18 BG BG069279A patent/BG44203A3/xx unknown
- 1985-03-18 MA MA20603A patent/MA20379A1/fr unknown
- 1985-03-18 ES ES541373A patent/ES541373A0/es active Granted
- 1985-03-18 HU HU85993A patent/HU194825B/hu unknown
- 1985-03-18 IL IL74630A patent/IL74630A/xx not_active IP Right Cessation
- 1985-03-18 FI FI851068A patent/FI85265C/fi not_active IP Right Cessation
- 1985-03-19 RO RO118054A patent/RO90953B/ro unknown
- 1985-03-19 PH PH32005A patent/PH20843A/en unknown
- 1985-03-19 CS CS851921A patent/CS250680B2/cs unknown
- 1985-03-19 OA OA58542A patent/OA07967A/xx unknown
-
1990
- 1990-11-30 JP JP2336861A patent/JPH03178963A/ja active Granted
-
1991
- 1991-04-11 DK DK064591A patent/DK165179C/da not_active IP Right Cessation
-
1992
- 1992-10-01 HK HK759/92A patent/HK75992A/en not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1667A patent/CY1667A/xx unknown
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